Endogenous Inhibition of Histone Deacetylase 1 by Tumor-Suppressive Maspin

Endogenous inhibition of histone deacetylase 1 by tumor-suppressive maspin.

Maspin, a noninhibitory serine protease inhibitor, exerts multifaceted tumor-suppressive effects. Maspin expression is associated with better differentiated phenotypes, better cancer prognosis, and better drug sensitivity. Consistently, maspin also correlates with increased expression of Bax and p21WAF1/CIP1. Interestingly, histone deacetylase 1 (HDAC1), a major HDAC responsible for histone dea...

Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin.

Maspin is a novel serine protease inhibitor with tumor suppressive activity, inhibiting tumor invasion and metastasis. To date, the underlying molecular mechanism of maspin remains elusive. Recombinant maspin has been shown to specifically inhibit cell surface-associated urokinase-type plasminogen activator (uPA) and fibrinogen-bound tissue-type plasminogen activator. However, the role of endog...

Inhibition of Histone Deacetylase Activity

Inhibition of Histone Deacetylase Suppresses

The Tumor-Suppressive Role Of Secreted Maspin Via The Exosomes

A TUMOR-SUPPRESSIVE ROLE OF MASPIN SECRETED VIA THE EXOSOMESbyIVORY DEANDecember 2014Advisor: Shijie Sheng, Ph.D. Major: Cancer BiologyDegree: Doctor of PhilosophyThis dissertation highlights several novel findings. Maspin has been consistentlydetected in the conditioned media of maspin-expressing cells of normal and tumorbreast, prostate and lung origin. Fur...